Instantaneous Normal Modes as an Unforced Reaction Coordinate for Protein Conformational Transitions
نویسندگان
چکیده
منابع مشابه
Coupling between normal modes drives protein conformational dynamics: illustrations using allosteric transitions in myosin II.
Structure-based elastic network models (ENMs) have been remarkably successful in describing conformational transitions in a variety of biological systems. Low-frequency normal modes are usually calculated from the ENM that characterizes elastic interactions between residues in contact in a given protein structure with a uniform force constant. To explore the dynamical effects of nonuniform elas...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.01.044